What to expect: The Sanibel Harbour Resort is nestled on a peninsula in a lush landscape with tropical palms.

Tall windows across the length of the lobby deliver a spectacular view of the pool and San Carlos Bay.

Amenity highlights: Five outdoor pools and one indoor exercise pool dot the resort’s 85 acres.

Tennis is played on five clay courts. The resort’s private yacht is the setting for brunch and dinner cruises.

The 40,000-square-foot spa provides 60 beauty and body care treatments, including water therapies, salt glows, and several incorporating Thalassotherapy with sea-derived products.